免疫原
Synthesized peptide derived from human SMURF1
特异性
This antibody detects endogenous levels of SMURF1 at Human, Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .
基因名称（Gene Name）
SMURF1 KIAA1625
蛋白名称
E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 6.3.2.-) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1)
细胞定位
Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
组织表达
Expressed in melanocytes (PubMed:23999003).
储存（Storage）
-15°C to -25°C/1 year(Do not lower than -25°C)
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