免疫原
Synthesized peptide derived from human SLC40A1. AA range 1-100
特异性
This antibody detects endogenous levels of SLC40A1 at Human, Mouse,Rat
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
功能
Major iron transporter that plays a key role in balancing cellular and systemic iron levels . Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma .
基因名称(Gene Name)
SLC40A1 FPN1 IREG1 SLC11A3 MSTP079
蛋白名称
Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
细胞定位
Cell membrane ; Multi-pass membrane protein . Localized to the basolateral membrane of polarized epithelial cells.
组织表达
Detected in erythrocytes (at protein level). Expressed in placenta, intestine, muscle and spleen.
储存(Storage)
-15°C to -25°C/1 year(Do not lower than -25°C)