免疫原
Synthesized peptide derived from human DAPK1 (Phospho Ser289)
特异性
This antibody detects endogenous levels of DAPK1 (Phospho Ser289) Rabbit pAb at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 IHC 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
death associated protein kinase 1(DAPK1) Homo sapiens Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Negatively regulated by autophosphorylation on Ser-308.,function:Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.,induction:Up-regulated following treatment with interferon-gamma.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 10 ANK repeats.,subcellular location:Colocalizes with the actin filament system.,
基因名称（Gene Name）
DAPK1 DAPK
蛋白名称
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
其他名称
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Fields
>>Autophagy - animal;>>Pathways in cancer;>>Bladder cancer
细胞定位
[Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton. Colocalizes with MAP1B in the microtubules and cortical actin fibers.; [Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton.
组织表达
Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomas.
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