免疫原
Synthesized peptide derived from human C-ternal STIM2
特异性
This antibody detects endogenous levels of STIM2 at Human, Mouse
组成（Formulation）
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
稀释比例
WB 1:500-2000 IHC 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.
基因名称（Gene Name）
STIM2 KIAA1482
蛋白名称
Stromal interaction molecule 2
其他名称
Stromal interaction molecule 2
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
组织表达
Expressed in all tissues and tumor cell lines examined.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
