免疫原
The antiserum was produced against synthesized peptide derived from human CDC25C around the phosphorylation site of Ser198. AA range:164-213
特异性
Phospho-Cdc25C (S198) Polyclonal Antibody detects endogenous levels of Cdc25C protein only when phosphorylated at S198.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
cell division cycle 25C(CDC25C) Homo sapiens This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015],
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,developmental stage:Expressed predominantly in G2 phase.,function:Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.,PTM:Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.,similarity:Belongs to the MPI phosphatase family.,similarity:Contains 1 rhodanese domain.,subunit:Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.,
蛋白名称
M-phase inducer phosphatase 3
其他名称
CDC25C; M-phase inducer phosphatase 3; Dual specificity phosphatase Cdc25C
Fields
>>Cell cycle;>>Oocyte meiosis;>>Progesterone-mediated oocyte maturation;>>Human immunodeficiency virus 1 infection;>>MicroRNAs in cancer
组织表达
Colon carcinoma,Epithelium,Skin,Testis,
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