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Prohibitin Monoclonal Antibody

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BYab-16564

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  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;FCM;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human Prohibitin expressed in E. Coli.
特异性
Prohibitin Monoclonal Antibody detects endogenous levels of Prohibitin protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
prohibitin(PHB) Homo sapiens This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
功能
developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging.,disease:Mutated in sporadic breast cancer.,function:Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.,induction:Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.,similarity:Belongs to the prohibitin family.,subunit:Interacts with PHB2.,tissue specificity:Widely expressed in different tissues.,
基因名称(Gene Name)
PHB
蛋白名称
Prohibitin
简称
Prohibitin
其他名称
PHB; Prohibitin
Fields
人基因ID
5245
人蛋白质序列数据库
P35232
小鼠基因ID
18673
小鼠蛋白质序列数据库
P67778
大鼠基因ID
25344
大鼠蛋白质序列数据库
P67779
细胞定位
Mitochondrion inner membrane . Nucleus . Cytoplasm . Cell membrane .
组织表达
Widely expressed in different tissues.
储存(Storage)
-20°C/1 year

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