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ASIC1 Polyclonal Antibody

说明书

BYab-16534

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;IHC-f;ELISA
分子量(DA)
55kD
免疫原
Synthetic peptide from human protein at AA range: 220-280
特异性
The antibody detects endogenous ASIC1
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012],
功能
alternative products:The splice variant from ASIC1a described in mouse and rat, which gives rise to an isoform with different N-termini (Asic1b), does not seem to exist in human,function:Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates a
基因名称(Gene Name)
ASIC1 ACCN2 BNAC2
蛋白名称
Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2) (BNaC2)
简称
ASIC1
其他名称
Acid-sensing ion channel 1 (ASIC1;Amiloride-sensitive cation channel 2, neuronal;Brain sodium channel 2;BNaC2)
Fields
>>Inflammatory mediator regulation of TRP channels
人基因ID
41
人蛋白质序列数据库
P78348
小鼠基因ID
11419
小鼠蛋白质序列数据库
Q6NXK8
大鼠基因ID
大鼠蛋白质序列数据库
P55926
细胞定位
Cell membrane ; Multi-pass membrane protein . Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4 (By similarity). .
组织表达
Expressed in most or all neurons.
储存(Storage)
-20°C/1 year

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ASIC1 Polyclonal Antibody

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