欢迎访问南京博研生物官网 服务热线:025-52298998 |
您当前的位置: 首页 > 产品中心 > 一抗 > 多克隆抗体

RhoGEF p115 Polyclonal Antibody

说明书

BYab-16247

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

产品简介 实验方案 引用文献 相关产品

产品简介>

宿主
反应性
应用
WB;ELISA;IHC
分子量(DA)
105kD
免疫原
The antiserum was produced against synthesized peptide derived from human ARHGEF1. AA range:162-211
特异性
RhoGEF p115 Polyclonal Antibody detects endogenous levels of RhoGEF p115 protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008],
功能
domain:The DH domain is involved in interaction with CCPG1.,domain:The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.,function:Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12.,PTM:Phosphorylated by PKCA.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 RGSL (RGS-like) domain.,subcellular location:Translocated to the membrane by activ
基因名称(Gene Name)
ARHGEF1
蛋白名称
Rho guanine nucleotide exchange factor 1
简称
RhoGEF p115
其他名称
ARHGEF1; Rho guanine nucleotide exchange factor 1; 115 kDa guanine nucleotide exchange factor; p115-RhoGEF; p115RhoGEF; Sub1.5
Fields
>>Vascular smooth muscle contraction;>>Platelet activation;>>Regulation of actin cytoskeleton;>>Parathyroid hormone synthesis, secretion and action;>>Pathogenic Escherichia coli infection;>>Yersinia infection;>>Human cytomegalovirus infection;>>Pathways in cancer;>>Proteoglycans in cancer;>>Lipid and atherosclerosis
人基因ID
9138
人蛋白质序列数据库
Q92888
小鼠基因ID
16801
小鼠蛋白质序列数据库
Q61210
大鼠基因ID
大鼠蛋白质序列数据库
Q9Z1I6
细胞定位
Cytoplasm . Membrane . Translocated to the membrane by activated GNA13 or LPA stimulation.
组织表达
Ubiquitously expressed.
储存(Storage)
-20°C/1 year

实验方案>

实验步骤

引用文献(0)>

相关产品>

成功添加到购物车

查看购物车 继续购物

RhoGEF p115 Polyclonal Antibody

筛选器: All

亮暗模式切换
X

在线
客服

在线客服
09:00 - 18:00

服务热线

服务
热线

客服服务热线

025-52298998
客服服务热线

扫码

扫码
咨询

微信二维码 微信扫一扫立即咨询
返回顶部 顶部