免疫原
The antiserum was produced against synthesized peptide derived from human RHOG. AA range:97-146
特异性
Rho G Polyclonal Antibody detects endogenous levels of Rho G protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011],
功能
function:Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:Interacts with SGEF.,
蛋白名称
Rho-related GTP-binding protein RhoG
其他名称
RHOG; ARHG; Rho-related GTP-binding protein RhoG
Fields
>>Bacterial invasion of epithelial cells;>>Salmonella infection;>>Yersinia infection
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
组织表达
Brain,PCR rescued clones,
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
