免疫原
The antiserum was produced against synthesized peptide derived from human CHML. AA range:128-177
特异性
REP-2 Polyclonal Antibody detects endogenous levels of REP-2 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008],
功能
function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family.,miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.,similarity:Belongs to the Rab GDI family.,subunit:Monomer. Interacts with Rab and Rab GGTase.,
蛋白名称
Rab proteins geranylgeranyltransferase component A 2
其他名称
CHML; REP2; Rab proteins geranylgeranyltransferase component A 2; Choroideraemia-like protein; Rab escort protein 2; REP-2
细胞定位
Cytoplasm, cytosol .
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