免疫原
The antiserum was produced against synthesized peptide derived from human RAB11FIP4. AA range:452-501
特异性
Rab11-FIP4 Polyclonal Antibody detects endogenous levels of Rab11-FIP4 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Apr 2008],
功能
function:A Rab11 effector protein acting in the endosomal trafficking.,similarity:Contains 1 EF-hand domain.,subcellular location:Colocalizes with RAB11A in the endocytic recycling compartment (ERC).,subunit:Homooligomer. Forms an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with RAB11A that has been activated by GTP binding.,
基因名称（Gene Name）
RAB11FIP4
蛋白名称
Rab11 family-interacting protein 4
其他名称
RAB11FIP4; ARFO2; KIAA1821; Rab11 family-interacting protein 4; FIP4-Rab11; Rab11-FIP4; Arfophilin-2
细胞定位
Endosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recycling endosome membrane ; Peripheral membrane protein. Cleavage furrow . Midbody . Cytoplasmic vesicle . Recruited to the cleavage furrow and the midbody during cytokinesis. .
组织表达
Present at high level in testis (at protein level). Weakly expressed in other tissues.
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