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Vav2 (phospho Tyr142) Polyclonal Antibody

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BYab-16118

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
101kD
免疫原
The antiserum was produced against synthesized peptide derived from human VAV2 around the phosphorylation site of Tyr142. AA range:108-157
特异性
Phospho-Vav2 (Y142) Polyclonal Antibody detects endogenous levels of Vav2 protein only when phosphorylated at Y142.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
浓度
1 mg/ml
背景(Background)
VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
功能
function:Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,tissue specificity:Widely expressed.,
基因名称(Gene Name)
VAV2
蛋白名称
Guanine nucleotide exchange factor VAV2
简称
VAV2
其他名称
VAV2; Guanine nucleotide exchange factor VAV2; VAV-2
Fields
>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Focal adhesion;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Yersinia infection;>>Proteoglycans in cancer;>>Lipid and atherosclerosis
人基因ID
7410
人蛋白质序列数据库
P52735
小鼠基因ID
22325
小鼠蛋白质序列数据库
Q60992
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
cytosol,plasma membrane,
组织表达
Widely expressed.
储存(Storage)
-20°C/1 year

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Vav2 (phospho Tyr142) Polyclonal Antibody

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