免疫原
Purified recombinant human Rab2 protein fragments expressed in E.coli.
特异性
This antibody detects endogenous levels of Rab2 and does not cross-react with related proteins.
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
功能
function:Required for protein transport from the endoplasmic reticulum to the Golgi complex.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with PRKCI.,
其他名称
9330148M11Rik;C80220;GTP binding protein;LHX;OTTMUSP00000004796;RAB2;RAB2 member RAS oncogene family;RAB2A;RAB2A, member RAS oncogene family;RAB2A_HUMAN;Ras related protein Rab 2A;RAS-associated protein RAB2;Ras-related protein Rab-2A;RP23-183L6.1;Small GTP binding protein RAB2A.
Fields
>>AMPK signaling pathway
细胞定位
Endoplasmic reticulum-Golgi intermediate compartment membrane ; Lipid-anchor . Melanosome . Endoplasmic reticulum membrane ; Lipid-anchor . Golgi apparatus membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, acrosome . Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
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