免疫原
The antiserum was produced against synthesized peptide derived from human IGF-I. AA range:100-149
特异性
IGF-I Polyclonal Antibody detects endogenous levels of IGF-I protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015],
功能
disease:Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.,function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.,online information:Insulin-like growth factor 1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the insulin family.,
蛋白名称
Insulin-like growth factor I
其他名称
IBP1; IGF-IA; IGF1A; IGFI; insulin-like growth factor 1; insulin-like growth factor IA; mechano growth factor; MGF; somatomedin C
细胞定位
extracellular region,extracellular space,plasma membrane,insulin-like growth factor binding protein complex,platelet alpha granule lumen,alphav-beta3 integrin-IGF-1-IGF1R complex,insulin-like growth factor ternary complex,exocytic vesicle,
组织表达
Brain,Liver,PCR rescued clones,
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