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OTX2 Monoclonal Antibody

说明书

BYab-15736

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;FCM;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human OTX2 expressed in E. Coli.
特异性
OTX2 Monoclonal Antibody detects endogenous levels of OTX2 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012],
功能
developmental stage:Embryo.,disease:Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures.,function:Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.,similarity:Belongs to the paired homeobox
基因名称(Gene Name)
OTX2
蛋白名称
Homeobox protein OTX2
简称
OTX2
其他名称
OTX2; Homeobox protein OTX2; Orthodenticle homolog 2
Fields
人基因ID
5015
人蛋白质序列数据库
P32243
小鼠基因ID
小鼠蛋白质序列数据库
P80206
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus .
组织表达
Eye,Retina,
储存(Storage)
-20°C/1 year

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OTX2 Monoclonal Antibody

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