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Nanog Monoclonal Antibody

说明书

BYab-15732

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of Nanog (aa20-166) expressed in E. Coli.
特异性
Nanog Monoclonal Antibody detects endogenous levels of Nanog protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],
功能
developmental stage:Expressed in embryonic stem (ES) and carcinoma (EC) cells. Expressed in inner cell mass (ICM) of the blastocyst and gonocytes between 14 and 19 weeks of gestation (at protein level). Not expressed in oocytes, unfertilized oocytes, 2-16 cell embryos and early morula (at protein level). Expressed in embryonic stem cells (ES). Expression decreases with ES differentiation.,function:May act as a transcription regulator (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.,function:Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 an
基因名称(Gene Name)
NANOG
蛋白名称
Homeobox protein NANOG
简称
Nanog
其他名称
NANOG; Homeobox protein NANOG; Homeobox transcription factor Nanog; hNanog
Fields
>>Signaling pathways regulating pluripotency of stem cells;>>Proteoglycans in cancer
人基因ID
79923
人蛋白质序列数据库
Q9H9S0
小鼠基因ID
小鼠蛋白质序列数据库
Q80Z64
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus .
组织表达
Expressed in testicular carcinoma and derived germ cell tumors (at protein level). Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes.
储存(Storage)
-20°C/1 year

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Nanog Monoclonal Antibody

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