免疫原
Synthesized peptide derived from human Claudin 3
特异性
The antibody can specifically recognize human Claudin 3 protein.
来源
Monoclonal Mouse IgG2b, kappa
组成（Formulation）
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
稀释比例
IHC-p 1:200-400, WB 1:200-1000,
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008],
功能
disease:Haploinsufficiency of CLDN3 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
基因名称（Gene Name）
CLDN3 C7orf1 CPETR2
蛋白名称
C7orf1;Claudin-3;Claudin3;CLD3_HUMAN;CLDN 3;Cldn3;Clostridium perfringens enterotoxin receptor 2;CPE R2;CPE receptor 2;CPE-R 2;CPE-receptor 2;CPETR 2;CPETR2;HRVP 1;HRVP1;Rat ventral prostate 1 like pr
其他名称
C7orf1;Claudin-3;Claudin3;CLD3_HUMAN;CLDN 3;Cldn3;Clostridium perfringens enterotoxin receptor 2;CPE R2;CPE receptor 2;CPE-R 2;CPE-receptor 2;CPETR 2;CPETR2;HRVP 1;HRVP1;Rat ventral prostate 1 like protein;Rat ventral prostate.1 protein homolog;RVP1;Ventral prostate.1 like protein;Ventral prostate.1 protein homolog
Fields
>>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
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