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MUM1 mouse mAb(ABT080)

说明书

BYab-15606

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
IHC;WB;IF
分子量(DA)
免疫原
Synthesized peptide derived from human MUM1
特异性
The antibody can specifically recognize human MUM1 protein.
来源
Mouse, Monoclonal/IgG1, Kappa
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.168% sodium azide.
稀释比例
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
背景(Background)
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010],
功能
disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,
基因名称(Gene Name)
IRF4 MUM1
蛋白名称
MUM1
简称
MUM1
其他名称
Interferon regulatory factor 4 (IRF-4;Lymphocyte-specific interferon regulatory factor;LSIRF;Multiple myeloma oncogene 1;NF-EM5)
Fields
>>Th17 cell differentiation
人基因ID
3662
人蛋白质序列数据库
Q15306
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Nucleus.
组织表达
Lymphoid cells.
储存(Storage)
-20°C/1 year

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MUM1 mouse mAb(ABT080)

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