免疫原
Synthesized peptide derived from human Thyroid Peroxidase(TPO)
特异性
This antibody detects endogenous levels of Thyroid Peroxidase(TPO) at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
功能
alternative products:Additional isoforms seem to exist,catalytic activity:2 iodide + H(2)O(2) + 2 H(+) = 2 iodine + 2 H(2)O.,cofactor:Binds 1 calcium ion per heterodimer.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer.,disease:An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.,disease:Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.,function:Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).,online information:Thyroid peroxidase entry,pathway:Hormone b
蛋白名称
Thyroid Peroxidase(TPO)
其他名称
Thyroid peroxidase (TPO;EC 1.11.1.8)
Fields
>>Tyrosine metabolism;>>Metabolic pathways;>>Thyroid hormone synthesis;>>Autoimmune thyroid disease
细胞定位
Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface.
组织表达
Glandular pool- thyroid,Spleen,Thyroid,
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