免疫原
Synthesized peptide derived from human MutS Protein Homolog 2(MSH2)
特异性
This antibody detects endogenous levels of MutS Protein Homolog 2(MSH2) at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:1500. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
功能
disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal
蛋白名称
MutS Protein Homolog 2(MSH2)
其他名称
DNA mismatch repair protein Msh2 (hMSH2;MutS protein homolog 2)
Fields
>>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer
细胞定位
Nucleus . Chromosome .
组织表达
Ubiquitously expressed.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
