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Arginase-1(ABT-Arg1) mouse mAb

说明书

BYab-15450

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
IHC,WB
分子量(DA)
免疫原
Synthesized peptide derived from human Arginase-1
特异性
This antibody detects endogenous levels of human Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as ant
来源
Mouse, Monoclonal/IgG2b, Kappa
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:100-500,WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
背景(Background)
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
功能
catalytic activity:L-arginine + H(2)O = L-ornithine + urea.,cofactor:Binds 2 manganese ions per subunit.,disease:Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.,induction:By arginine or homoarginine.,online information:Arginase entry,pathway:Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.,similarity:Belongs to the arginase family.,subunit:Homotrimer.,
基因名称(Gene Name)
ARG1
蛋白名称
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
简称
Arginase I
其他名称
Fields
>>Arginine biosynthesis;>>Arginine and proline metabolism;>>Metabolic pathways;>>Biosynthesis of amino acids;>>Amoebiasis
人基因ID
383
人蛋白质序列数据库
P05089
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm . Cytoplasmic granule . Localized in azurophil granules of neutrophils (PubMed:15546957). .
组织表达
Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409).
储存(Storage)
-20°C/1 year

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Arginase-1(ABT-Arg1) mouse mAb

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