免疫原
Synthesized peptide derived from human Stathmin
特异性
The antibody can specifically recognize human Stathmin protein. In western blotting of Hela cell lysate, the antibody can label a 17 kDa band corresponding to Stathmin.
来源
Monoclonal Mouse IgG2b, kappa
组成（Formulation）
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
稀释比例
IHC-p 1:200-400,WB: 500-1000
纯化工艺（Immunogen）
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
背景（Background）
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009],
功能
disease:Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.,function:Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.,PTM:Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at
基因名称（Gene Name）
STMN1 C1orf215 LAP18 OP18
蛋白名称
C1orf215;Lag;LAP 18;LAP18;Leukemia associated phosphoprotein p18;Leukemia-associated phosphoprotein p18;Metablastin;Oncoprotein 18;OP 18;Op18;p18;p19;Phosphoprotein 19;Phosphoprotein p19;pp17;pp19;PR2
其他名称
C1orf215;Lag;LAP 18;LAP18;Leukemia associated phosphoprotein p18;Leukemia-associated phosphoprotein p18;Metablastin;Oncoprotein 18;OP 18;Op18;p18;p19;Phosphoprotein 19;Phosphoprotein p19;pp17;pp19;PR22;Pr22 protein;Prosolin;Protein Pr22;SMN;Stathmin;Stathmin1;STMN 1;Stmn1;STMN1_HUMAN
Fields
>>MAPK signaling pathway;>>MicroRNAs in cancer
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