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Glucagon (PT1696) mouse mAb

说明书

BYab-15168

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宿主
反应性
应用
IHC;IF
分子量(DA)
免疫原
Synthesized peptide derived from human Glucagon
特异性
This antibody detects endogenous levels of human Glucagon. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
来源
Mouse, Monoclonal/IgG2b, Kappa
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1:100-500. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
浓度
背景(Background)
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008],
功能
function:Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.,function:GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis.,function:GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, c
基因名称(Gene Name)
GCG
蛋白名称
Glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM) (OXY); Glucagon; Glucagon-like peptide 1 (GLP-1) (Incretin hormone); Glucagon-like peptide 1(7-37) (GLP-1(7
简称
Glucagon
其他名称
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Thermogenesis;>>Insulin secretion;>>Glucagon signaling pathway
人基因ID
2641
人蛋白质序列数据库
P01275
小鼠基因ID
小鼠蛋白质序列数据库
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Secreted .; [Glucagon-like peptide 1]: Secreted .
组织表达
[Glucagon]: Secreted in the A cells of the islets of Langerhans. ; [Glucagon-like peptide 1]: Secreted in the A cells of the islets of Langerhans (PubMed:22037645). Secreted from enteroendocrine L cells throughout the gastrointestinal tract (PubMed:22037645). Also secreted in selected neurons in the brain. ; [Glucagon-like peptide 2]: Secreted from enteroendocrine cells throughout the gastrointestinal tract. Also secreted in selected neurons in the brain.; [Glicentin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract.; [Oxyntomodulin]: Secreted from enteroendocrine cells throughout the gastrointestinal tract.
储存(Storage)
-20°C/1 year

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Glucagon (PT1696) mouse mAb

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