免疫原
The antiserum was produced against synthesized peptide derived from human KAPCG. AA range:1-50
特异性
PKAγ cat Polyclonal Antibody detects endogenous levels of PKAγ cat protein.
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景(Background)
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by cAMP.,function:Phosphorylates a large number of substrates in the cytoplasm and the nucleus.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subunit:A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.,tissue specificity:Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.,
蛋白名称
cAMP-dependent protein kinase catalytic subunit gamma
其他名称
PRKACG; cAMP-dependent protein kinase catalytic subunit gamma; PKA C-gamma
Fields
>>Endocrine resistance;>>MAPK signaling pathway;>>Ras signaling pathway;>>Calcium signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Oocyte meiosis;>>Autophagy - animal;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Apelin signaling pathway;>>Tight junction;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Thermogenesis;>>Long-term potentiation;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Olfactory transduction;>>Taste transduction;>>Inflammatory mediator regulation of TRP channels;>>Insulin signaling pathway;>>Insulin secretion;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Thyroid hormo
细胞定位
nucleoplasm,cytosol,ciliary base,
组织表达
Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.