免疫原
The antiserum was produced against synthesized peptide derived from human Hexokinase-3. AA range:811-860
特异性
HXK III Polyclonal Antibody detects endogenous levels of HXK III protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009],
功能
catalytic activity:ATP + D-hexose = ADP + D-hexose 6-phosphate.,domain:The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.,enzyme regulation:Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.,miscellaneous:In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).,online information:Hexokinase entry,pathway:Carbohydrate metabolism; hexose metabolism.,similarity:Belongs to the hexokinase family.,subunit:Monomer.,
其他名称
HK3; Hexokinase-3; Hexokinase type III; HK III
Fields
>>Glycolysis / Gluconeogenesis;>>Fructose and mannose metabolism;>>Galactose metabolism;>>Starch and sucrose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Neomycin, kanamycin and gentamicin biosynthesis;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of nucleotide sugars;>>HIF-1 signaling pathway;>>Insulin signaling pathway;>>Type II diabetes mellitus;>>Carbohydrate digestion and absorption;>>Shigellosis;>>Central carbon metabolism in cancer
细胞定位
cell,mitochondrion,cytosol,
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