免疫原
The antiserum was produced against synthesized peptide derived from human DAK. AA range:91-140
特异性
DHA Kinase Polyclonal Antibody detects endogenous levels of DHA Kinase protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + glycerone = ADP + glycerone phosphate.,catalytic activity:FAD = AMP + riboflavin cyclic-4',5'-phosphate.,cofactor:Magnesium.,cofactor:Manganese or cobalt; for FAD-AMP lyase activity.,enzyme regulation:Each activity is inhibited by the substrate(s) of the other.,function:Catalyzes both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.,similarity:Belongs to the dihydroxyacetone kinase (DAK) family.,similarity:Contains 1 DAK1 (dihydroxyacetone kinase subunit 1) domain.,similarity:Contains 1 DAK2 (dihydroxyacetone kinase subunit 2) domain.,subunit:Homodimer.,
蛋白名称
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase
其他名称
DAK; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase; cyclizing
Fields
>>Fructose and mannose metabolism;>>Glycerolipid metabolism;>>Metabolic pathways;>>Carbon metabolism;>>RIG-I-like receptor signaling pathway
细胞定位
nucleus,cytosol,extracellular exosome,
组织表达
Detected in erythrocytes (at protein level).
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