免疫原
The antiserum was produced against synthesized peptide derived from human KAD1 . AA range:101-150
特异性
AK1 Polyclonal Antibody detects endogenous levels of AK1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
adenylate kinase 1(AK1) Homo sapiens This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
功能
catalytic activity:ATP + AMP = 2 ADP.,disease:Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency [MIM:612631].,function:Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.,online information:Adenylate kinase entry,polymorphism:This enzyme represents the most common of at least five alleles.,similarity:Belongs to the adenylate kinase family.,subunit:Monomer.,
蛋白名称
Adenylate kinase isoenzyme 1
其他名称
AK1; Adenylate kinase isoenzyme 1; AK 1; ATP-AMP transphosphorylase 1; Myokinase
Fields
>>Purine metabolism;>>Thiamine metabolism;>>Metabolic pathways;>>Nucleotide metabolism;>>Biosynthesis of cofactors
组织表达
Chondrosarcoma Lung Metastasis,Colon,Fetal brain cortex,Retina,Skeletal muscle,Synovial mem
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