免疫原
Synthesized peptide derived from human RSK3 (Phospho Thr353)
特异性
This antibody detects endogenous levels of Human,Mouse RSK3 (Phospho Thr353)
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:1000-2000 ELISA 1:5000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,
功能
protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, phosphorylation,
基因名称（Gene Name）
RPS6KA2 MAPKAPK1C RSK3
蛋白名称
RSK3 (Phospho Thr353)
其他名称
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2;EC 2.7.11.1;90 kDa ribosomal protein S6 kinase 2;p90-RSK 2;p90RSK2;MAP kinase-activated protein kinase 1c;MAPK-activated protein kinase 1c;MAPKAP kinase 1c;MAPKAPK-1c;Ribosomal S6 kinase 3;RSK-3;pp90RSK3)
Fields
>>MAPK signaling pathway;>>Oocyte meiosis;>>mTOR signaling pathway;>>Thermogenesis;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Progesterone-mediated oocyte maturation;>>Insulin resistance;>>Yersinia infection;>>Chemical carcinogenesis - receptor activation
细胞定位
Nucleus . Cytoplasm .
组织表达
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
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