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Tec Monoclonal Antibody

说明书

BYab-14192

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of Tec expressed in E. Coli.
特异性
Tec Monoclonal Antibody detects endogenous levels of Tec protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:It is uncertain whether Met-1 is the initiator.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with INPP5D/SHIP1 and INPPL1/SHIP2.,tissue specificity:Hematopoietic cell lines including myeloid, B-, and T-cell lineages.,
基因名称(Gene Name)
TEC
蛋白名称
Tyrosine-protein kinase Tec
简称
Tec
其他名称
TEC; PSCTK4; Tyrosine-protein kinase Tec
Fields
>>Osteoclast differentiation;>>T cell receptor signaling pathway
人基因ID
7006
人蛋白质序列数据库
P42680
小鼠基因ID
小鼠蛋白质序列数据库
P24604
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). .
组织表达
Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.
储存(Storage)
-20°C/1 year

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Tec Monoclonal Antibody

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