免疫原
The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50
特异性
TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],
功能
similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.,
蛋白名称
Transmembrane 4 L6 family member 1
其他名称
TM4SF1; M3S1; TAAL6; Transmembrane 4 L6 family member 1; Membrane component chromosome 3 surface marker 1; Tumor-associated antigen L6
细胞定位
Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). .
组织表达
Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.
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