免疫原
Synthesized peptide derived from CD164 . at AA range: 110-190
特异性
CD164 Polyclonal Antibody detects endogenous levels of CD164 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008],
功能
function:This is a carcinoma-associated protein, probably a mucin.,PTM:Highly N- and O-glycosylated; contains sialic acid.,PTM:The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.,similarity:Belongs to the CD164 family.,tissue specificity:Small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma.,
蛋白名称
Sialomucin core protein 24
其他名称
CD164; Sialomucin core protein 24; MUC-24; Endolyn; Multi-glycosylated core protein 24; MGC-24; MGC-24v; CD antigen CD164
细胞定位
Lysosome membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
组织表达
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
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