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Podocalyxin-like 1 Monoclonal Antibody

说明书

BYab-13820

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;FCM;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of human Podocalyxin-like 1 expressed in E. Coli.
特异性
Podocalyxin-like 1 Monoclonal Antibody detects endogenous levels of Podocalyxin-like 1 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
podocalyxin like(PODXL) Homo sapiens This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008],
功能
function:Functions as an antiadhesin that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion.,PTM:Glycosylated; contains sialic acid.,similarity:Belongs to the podocalyxin family.,tissue specificity:Glomerular epithelium cell (podocyte).,
基因名称(Gene Name)
PODXL
蛋白名称
Podocalyxin
简称
Podocalyxin-like 1
其他名称
PODXL; PCLP; PCLP1; Podocalyxin; GCTM-2 antigen; Gp200; Podocalyxin-like protein 1; PC; PCLP-1
Fields
>>Salmonella infection
人基因ID
5420
人蛋白质序列数据库
O00592
小鼠基因ID
小鼠蛋白质序列数据库
Q9R0M4
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Apical cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus . Membrane raft . Membrane ; Single-pass type I membrane protein . In single attached epithelial cells is restricted to a preapical pole on the free plasma membrane whereas other apical and basolateral proteins are not yet polarized. Colocalizes with SLC9A3R2 at the apical plasma membrane during epithelial polarization. Colocalizes with SLC9A3R1 at the trans-Golgi network (transiently) and at the apical plasma membrane. Its association with the membrane raft is transient. Colocalizes with actin filaments, EZR and SLC9A3R1 in a punctate pattern at the apical cell surface where microvilli form. Colocalizes with EZR and SLC9A3R2 at the apical cell membrane o
组织表达
Glomerular epithelium cell (podocyte).
储存(Storage)
-20°C/1 year

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Podocalyxin-like 1 Monoclonal Antibody

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