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CD10 Monoclonal Antibody

说明书

BYab-13785

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB;IHC;IF;ELISA
分子量(DA)
免疫原
Purified recombinant fragment of CD10 expressed in E. Coli.
特异性
CD10 Monoclonal Antibody detects endogenous levels of CD10 protein.
来源
Monoclonal, Mouse
组成(Formulation)
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
稀释比例
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
纯化工艺(Immunogen)
Affinity purification
浓度
背景(Background)
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this
功能
catalytic activity:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.,cofactor:Binds 1 zinc ion per subunit.,disease:Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.,enzyme regulation:Inhibited in a dose dependent manner by opiorphin.,function:Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Involved in the degradation of atrial natriuretic factor (ANF).,similarity:Belongs to the peptidase M13 family.,
基因名称(Gene Name)
MME
蛋白名称
Neprilysin
简称
CD10
其他名称
MME; EPN; Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD antigen CD10
Fields
>>Renin-angiotensin system;>>Hematopoietic cell lineage;>>Protein digestion and absorption;>>Alzheimer disease
人基因ID
4311
人蛋白质序列数据库
P08473
小鼠基因ID
小鼠蛋白质序列数据库
Q61391
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cell membrane; Single-pass type II membrane protein.
组织表达
Adrenal cortex,Brain,Kidney,Placenta,
储存(Storage)
-20°C/1 year

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CD10 Monoclonal Antibody

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