免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PTGER1. AA range:191-240
特异性
EP1 Polyclonal Antibody detects endogenous levels of EP1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008],
功能
function:Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.,PTM:Phosphorylated .,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.,
蛋白名称
Prostaglandin E2 receptor EP1 subtype
其他名称
PTGER1; Prostaglandin E2 receptor EP1 subtype; PGE receptor EP1 subtype; PGE2 receptor EP1 subtype; Prostanoid EP1 receptor
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Human cytomegalovirus infection;>>Pathways in cancer
细胞定位
Cell membrane; Multi-pass membrane protein.
组织表达
Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
