免疫原
Synthesized peptide derived from the Internal region of human IL-28Rα.
特异性
IL-28Rα Polyclonal Antibody detects endogenous levels of IL-28Rα protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
功能
function:The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,similarity:Belongs to the type II cytokine receptor family.,similarity:Contains 1 fibronectin type-III domain.,subunit:Heterodimer with IL10RB.,tissue specificity:Widely expressed.,
蛋白名称
Interleukin-28 receptor subunit alpha
其他名称
IL28RA; IFNLR1; LICR2; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12;CRF2-12; Interferon lambda receptor 1; IFN-lambda receptor 1; IFN-lambda-R1; Likely interleukin or cytokine receptor 2; LICR2
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway
细胞定位
Membrane ; Single-pass type I membrane protein .
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