免疫原
The antiserum was produced against synthesized peptide derived from human TAS2R16. AA range:136-185
特异性
T2R16 Polyclonal Antibody detects endogenous levels of T2R16 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008],
功能
function:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.,miscellaneous:Confers bitter perception of salicin to non-taster mice.,miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell.,polymorphism:The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780].,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in a subset of gustducin-positive taste receptor cells of the tongue.,
蛋白名称
Taste receptor type 2 member 16
其他名称
TAS2R16; Taste receptor type 2 member 16; T2R16
Fields
>>Taste transduction
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Expressed in a subset of gustducin-positive taste receptor cells of the tongue. Expressed in circumvallate papillae and testis (PubMed:16720576).
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