免疫原
The antiserum was produced against synthesized peptide derived from human EDG7. AA range:281-330
特异性
EDG-7 Polyclonal Antibody detects endogenous levels of EDG-7 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
lysophosphatidic acid receptor 3(LPAR3) Homo sapiens This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008],
功能
function:Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.,
蛋白名称
Lysophosphatidic acid receptor 3
其他名称
LPAR3; EDG7; LPA3; Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7
Fields
>>Rap1 signaling pathway;>>Phospholipase D signaling pathway;>>Neuroactive ligand-receptor interaction;>>PI3K-Akt signaling pathway;>>Pathways in cancer
细胞定位
Cell membrane; Multi-pass membrane protein.
组织表达
Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
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