免疫原
The antiserum was produced against synthesized peptide derived from human CCKAR. AA range:215-264
特异性
CCK-AR Polyclonal Antibody detects endogenous levels of CCK-AR protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008],
功能
function:Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.,online information:Cholecystokinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
蛋白名称
Cholecystokinin receptor type A
其他名称
CCKAR; CCKRA; Cholecystokinin receptor type A; CCK-A receptor; CCK-AR; Cholecystokinin-1 receptor; CCK1-R
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Insulin secretion;>>Pancreatic secretion
细胞定位
Cell membrane; Multi-pass membrane protein.
组织表达
Gall bladder,Peripheral blood leukocyte,Stomach,
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