免疫原
The antiserum was produced against synthesized peptide derived from human BDKRB1. AA range:201-250
特异性
Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
功能
function:This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.,online information:Bradykinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
蛋白名称
B1 bradykinin receptor
其他名称
BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Complement and coagulation cascades;>>Inflammatory mediator regulation of TRP channels;>>Regulation of actin cytoskeleton;>>Pathways in cancer
细胞定位
Cell membrane; Multi-pass membrane protein.
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