免疫原
The antiserum was produced against synthesized peptide derived from human OPRK1. AA range:321-370
特异性
KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016],
功能
function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.,online information:Kappa opioid receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SLC9A3R1. Interacts with GABARAPL1.,
蛋白名称
Kappa-type opioid receptor
其他名称
OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
Fields
>>Neuroactive ligand-receptor interaction
细胞定位
Cell membrane ; Multi-pass membrane protein .
组织表达
Detected in brain and placenta.
联系我们
关注我们
您当前的位置： 
说明书
成功添加到购物车
