免疫原
The antiserum was produced against synthesized peptide derived from human CBLN3. AA range:131-180
特异性
Cerebellin 3 Polyclonal Antibody detects endogenous levels of Cerebellin 3 protein.
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
背景（Background）
Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009],
功能
function:May be involved in synaptic functions in the CNS.,similarity:Contains 1 C1q domain.,subcellular location:Secretion depends probably on a association with CBLN1 or perhaps CBLN4 but not on CBLN2.,subunit:Heterohexamer; disulfide-linked heterotrimers. Does not homooligomerize, but probably forms a complex with at least CBLN1. May interact with CBLN2 and CBLN4.,
细胞定位
Endoplasmic reticulum . Golgi apparatus, cis-Golgi network . Secreted . Cell junction, synapse . In the absence of CBLN1, remains in the endoplasmic reticulum/cis-Golgi apparatus. Partial secretion depends on an association with CBLN1 and maybe CBLN4, but not on CBLN2 (By similarity). .
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