免疫原
Synthesized peptide derived from human DCNL3 AA range: 205-255
特异性
This antibody detects endogenous levels of DCNL3 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
功能
similarity:Contains 1 DCUN1 domain.,
细胞定位
Cell membrane . Cytoplasm . Nucleus . Cytoplasm, perinuclear region . After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). .
组织表达
Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).
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