免疫原
Synthesized peptide derived from human GLYM AA range: 122-172
特异性
This antibody detects endogenous levels of GLYM at Human
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
功能
catalytic activity:5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.,cofactor:Pyridoxal phosphate.,function:Interconversion of serine and glycine.,miscellaneous:In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.,pathway:One-carbon metabolism; tetrahydrofolate pathway.,similarity:Belongs to the SHMT family.,subunit:Homotetramer.,
Fields
>>Glycine, serine and threonine metabolism;>>Glyoxylate and dicarboxylate metabolism;>>One carbon pool by folate;>>Metabolic pathways;>>Carbon metabolism;>>Biosynthesis of amino acids;>>Biosynthesis of cofactors;>>Antifolate resistance
细胞定位
Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . Mitochondrion inner membrane . Cytoplasm . Nucleus . Mainly localizes in the mitochondrion. Also found in the cytoplasm and nucleus as part of the BRISC complex (PubMed:24075985). .
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