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FHOD1 rabbit pAb

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BYab-12143

  • 20UL ¥460 50UL ¥945 100UL ¥1350
  • 货期: 3天左右

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宿主
反应性
应用
WB
分子量(DA)
免疫原
Synthesized peptide derived from human FHOD1 AA range: 210-260
特异性
This antibody detects endogenous levels of FHOD1 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
浓度
1 mg/ml
背景(Background)
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
功能
domain:Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein.,function:Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.,similarity:Belongs to the formin homology family.,similarity:Contains 1 FH1 (formin homology 1) domain.,similarity:Contains 1 FH2 (formin homology 2) domain.,similarity:Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.,subcellular location:Predominantly cytoplasmic.,subunit:Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus.,tissue specificity:Ubiquitous. Highly expressed in spleen.,
基因名称(Gene Name)
FHOD1 FHOS FHOS1
蛋白名称
FHOD1
简称
FHOD1
其他名称
Fields
>>Salmonella infection
人基因ID
29109
人蛋白质序列数据库
Q9Y613
小鼠基因ID
234686
小鼠蛋白质序列数据库
Q6P9Q4
大鼠基因ID
大鼠蛋白质序列数据库
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Predominantly cytoplasmic.
组织表达
Ubiquitous. Highly expressed in spleen.
储存(Storage)
-20°C/1 year

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FHOD1 rabbit pAb

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