免疫原
Synthesized peptide derived from human GPAT4 AA range: 39-89
特异性
This antibody detects endogenous levels of GPAT4 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004],
功能
catalytic activity:Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.,domain:The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.,enzyme regulation:Inhibited by N-ethylmaleimide (NEM).,function:Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.,pathway:Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3.,similarity:Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.,tissue specificity:Ubiquitous. Relatively high level of expression in skeletal muscle, heart and testis. Relatively low level of expression in lung.,
基因名称（Gene Name）
AGPAT6 GPAT4 UNQ551/PRO1108
Fields
>>Glycerolipid metabolism;>>Glycerophospholipid metabolism;>>Metabolic pathways
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
组织表达
Ubiquitous. High levels in testis. Relatively high level of expression in skeletal muscle and heart. Relatively low level of expression in lung.
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