免疫原
Synthesized peptide derived from human DYL1 AA range: 1-50
特异性
This antibody detects endogenous levels of DYL1 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
IHC-p 1：50-200. IF 1:50-200
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],
功能
function:Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.,function:May be involved in some aspects of dynein-related intracellular transport and motility. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.,similarity:Belongs to the dynein light chain family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Interacts with rabies P protein (By similarity). Interacts with TXNDC17.,tissue specificity:Ubiquitous.,
基因名称（Gene Name）
DYNLL1 DLC1 DNCL1 DNCLC1 HDLC1
Fields
>>Vasopressin-regulated water reabsorption;>>Salmonella infection
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton . Nucleus . Mitochondrion . Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. .
组织表达
Ubiquitous (PubMed:8628263). Expressed in testis (PubMed:22965910).
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