免疫原
Synthesized peptide derived from human ZFYV1 AA range: 318-368
特异性
This antibody detects endogenous levels of ZFYV1 at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
功能
sequence caution:Translated as Trp.,similarity:Contains 2 FYVE-type zinc fingers.,subcellular location:Resides predominantly in the cisternal stacks of the Golgi.,subunit:Binds to phosphatidylinositol-3-phosphate (PtdIns3P) through its FYVE-type zinc finger.,tissue specificity:Isoform 1 was expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Both isoforms, 1 and 2 showed a high expression in heart. Isoform 2 is also detected in the testis.,
基因名称（Gene Name）
ZFYVE1 DFCP1 KIAA1589 TAFF1 ZNFN2A1 PP10436
Fields
>>Autophagy - animal;>>Pathways of neurodegeneration - multiple diseases
细胞定位
Golgi apparatus, Golgi stack . Golgi apparatus . Endoplasmic reticulum . Lipid droplet . Preautophagosomal structure . Mitochondrion . Resides predominantly in the cisternal stacks of the Golgi (PubMed:11256955). Colocalizes with TRIM13 on the perinuclear endoplasmic reticulum (PubMed:22178386). During starvation conditions, localizes to omegasomes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (PubMed:31293035, PubMed:25876663). Localizes to lipid droplets in the presence of oleic acid (PubMed:31293035, PubMed:30970241). .
组织表达
[Isoform 2]: Highly expressed in heart. Also detected in the testis. ; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart.
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