免疫原
Synthesized peptide derived from human SC6A9 AA range: 101-151
特异性
This antibody detects endogenous levels of SC6A9 at Human/Mouse/Rat
来源
Polyclonal, Rabbit,IgG
组成(Formulation)
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
稀释比例
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
纯化工艺(Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景(Background)
The amino acid glycine acts as an inhibitory neurotransmitter in the central nervous system. The protein encoded by this gene is one of two transporters that stop glycine signaling by removing it from the synaptic cleft. [provided by RefSeq, Jun 2016],
功能
function:Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,tissue specificity:All GLYT-1 subtypes can be found in brain, kidney, pancreas, lung, placenta, liver. But GLYT-1C subtype is only found in the brain.,
Fields
>>Synaptic vesicle cycle
细胞定位
Membrane; Multi-pass membrane protein.
组织表达
Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.