WB

Synthesized peptide derived from human DOXA1 AA range: 24-74

This antibody detects endogenous levels of DOXA1 at Human/Mouse

Polyclonal, Rabbit,IgG

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

WB 1：500-2000

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013],

function:May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1.,similarity:Belongs to the DUOXA family.,subunit:May interact with NUMB.,tissue specificity:Specifically expressed in thyroid gland. Also detected in esophagus.,

DUOXA1 NIP NUMBIP

DOXA1

DOXA1

90527

Q1HG43

213696

Q8VE49

Membrane ; Multi-pass membrane protein .

Specifically expressed in thyroid gland. Also detected in esophagus.

-20°C/1 year