免疫原
Synthesized peptide derived from human OTOAN AA range: 1044-1094
特异性
This antibody detects endogenous levels of OTOAN at Human/Mouse
来源
Polyclonal, Rabbit,IgG
组成（Formulation）
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺（Immunogen）
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
背景（Background）
The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
功能
disease:Defects in OTOA are the cause of non-syndromic sensorineural deafness autosomal recessive type 22 (DFNB22) [MIM:607039]. DFNB22 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:May act as an adhesion molecule.,similarity:Belongs to the stereocilin family.,subcellular location:At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes.,
细胞定位
Apical cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side . Secreted, extracellular space, extracellular matrix . At the interface between the apical surface of the epithelia and the overlying acellular gel of the tectorial and otoconial membranes. .
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